Epidermal growth factor receptor and bladder cancer
نویسندگان
چکیده
منابع مشابه
Epidermal growth factor receptor and bladder cancer.
Muscle-invasive bladder cancer is a disease which causes significant morbidity and mortality. The two main forms of treatment for this disease include radical cystectomy and radical radiotherapy, but five year survival after treatment remains low at 40%. Many clinical and molecular risk factors have been shown to be associated with poor prognosis. One such factor is the expression of epidermal ...
متن کاملTargeting the Epidermal Growth Factor Receptor in Bladder Cancer
The Epidermal Growth Factor Receptor (EGFR), or ErbB1, is a member of the ErbB family of tyrosine kinase receptors. It is a 170 kDa transmembrane glycoprotein that can bind a variety of ligands on its extracellular domain, most notably Epidermal Growth Factor (EGF). Binding of ligand induces homoor heterodimerization with a second EGFR molecule or another member of the ErbB family, respectively...
متن کاملAltered Expression of Epidermal Growth Factor Receptor (EGFR) in Glioma
EGFR is a key molecule in cancer cells. EGFR signaling was shown to promote tumor cell proliferation and survival, invasion and angiogenesis and mediate resistance to treatment, including ionizing radiation in preclinical models. We extracted proteins from astrocytoma (III and IV) oligodendroglioma(IV) tumors and normal brain tissues and then evaluated the protein purity by Bradford test ...
متن کاملAssessment of epidermal growth factor receptor status in glioblastomas
Objective(s): Our previous study showed that a newly designed tracer radioiodinated 6-(3-morpholinopropoxy)-7-ethoxy-4-(3'-iodophenoxy)quinazoline ([125I]PYK) is promising for the evaluation of the epidermal growth factor receptor (EGFR) status and prediction of gefitinib treatment of non-small cell lung cancer. EGFR is over-expressed and mutated also in glioblastoma. In the present study, the ...
متن کاملDetection of circulating cancer cells expressing uroplakins and epidermal growth factor receptor in bladder cancer patients.
Our purpose was to determine the clinical relevance of the detection of circulating tumor cells (CTCs) expressing urothelial and epithelial markers in bladder cancer patients. Sixty-two patients who presented to Memorial Sloan-Kettering Cancer Center between July 2000 and September 2001 were studied. Peripheral blood was tested by nested RT-PCR assay for uroplakins (UPs) Ia, Ib, II and III as w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 2002
ISSN: 0032-5473
DOI: 10.1136/pmj.78.924.584